The most common drug-related adverse reactions in patients with advanced NSCLC treated with nintedanib monotherapy were nausea (57.5%), diarrhea (47.9%), vomiting (42.5%), anorexia (28.8%), abdominal pain (13.7%), and reversible elevation of alanine aminotransferase (13.7%) and aspartate aminotransferase (9.6%) levels (172). This evidence concerns the gene GPT and non-small cell lung carcinoma.