The expression level of NDUFAF2 was markedly greater in tumor tissues, such as adrenocortical carcinoma (ACC), cholangiocarcinoma (CHOL), diffuse large B cell lymphoma (DLBCL), glioblastoma multiforme (GBM), kidney renal papillary cell carcinoma (KIRP), kidney renal clear cell carcinoma (KIRC), low-grade glioma (LGG), LUAD, liver hepatocellular carcinoma (LIHC), prostate adenocarcinoma (PRAD), pancreas adenocarcinoma (PAAD), skin cutaneous melanoma (SKCM), rectal adenocarcinoma (READ), thymoma (THYM), stomach adenocarcinoma (STAD), and thyroid carcinoma (THCA). Here, NDUFAF2 is linked to cholangiocarcinoma.