However, another study illustrated that serum Nrg4 levels were not associated with NAFLD, hepatic fat fraction, and NAFLD-associated fibrosis in patients where chemical shift magnetic resonance imaging and transient elastography were used to diagnose NAFLD and associated fibrosis, respectively (De Munck TJIBoesch et al., 2021). Here, NRG4 is linked to metabolic dysfunction-associated steatotic liver disease.