These adipokines have been characterized as exhibiting effects that can ameliorate metabolic dysregulation in obesity (Achari and Jain, 2017; Milek et al., 2022; Zhou et al., 2022), suggesting that Nrg4 overexpression can further contribute to the normalization of the adipokine profile. This evidence concerns the gene NRG4 and obesity due to melanocortin 4 receptor deficiency.