Reduced Nrg4 levels were observed in mice and human samples with inflammatory bowel disease, and Nrg4 treatment blocked inflammatory cytokine-induced apoptosis of colonic epithelial cells both in vivo and in vitro, which demonstrated the potential anti-inflammatory effect of Nrg4-ErbB4 signaling (Bernard et al., 2012; McElroy et al., 2014). The gene discussed is NRG4; the disease is inflammatory bowel disease.