Eken et al. (Kurek Eken et al., 2018) concluded that circulating Nrg4 concentrations were increased in GDM patients, while other studies (Kralisch et al., 2018; Zhang et al., 2021; Attique et al., 2022; Li et al., 2022) have observed the opposite trend. This evidence concerns the gene NRG4 and gestational diabetes.