Serum Nrg4 levels were negatively correlated with inflammatory marker high-sensitivity C-reactive protein (hs-CRP) levels (Yan et al., 2017) and the development of MetS (Yan et al., 2018) in patients with diabetes, suggesting a potential relevance of reduced circulating levels of Nrg4 in T2DM in the pathogenesis of inflammation and metabolic dysregulation. This evidence concerns the gene NRG4 and type 2 diabetes mellitus.