PRRT2 and Hyperglycemia: Examples of potential mechanisms to explore include chronic low-grade inflammation (Copp et al., 2015; Xing et al., 2018) and/or oxidative stress (Harms et al., 2017), PKC-induced transient receptor potential vanilloid 1 (TRPV1) overactivity caused by hyperglycemia (Ishizawa et al., 2021), and changes in body weight and skeletal muscle mass and/or fiber type (Petrofsky et al., 1981; Estrada et al., 2020).