Additionally, the putative targets of miR-497-5p including PSMD7, CCND3, SMURF2, and WNT7A increase chemoresistance in gastric cancer, acute myeloid leukemia, lung cancer and OSCC, respectively (Tian et al., 2018; Ray et al., 2020; Smith et al., 2021; Wang et al., 2021). This evidence concerns the gene SMURF2 and gastric cancer.