Based on the co-expressed genes of DEFA5 and DEFA6, we found that the co-expressed genes shared by DEFA5 and DEFA6: KLK12, PTGDR2, ATOH1, OLFM4, and CLCA1were involved in tumor formation, inflammatory response, transcriptional regulation, inhibition of cell growth, induction of cell differentiation and apoptosis, and promotion of cell adhesion and tumor inhibition. The gene discussed is KLK12; the disease is neoplasm.