DEFA5 and neoplasm: Based on the co-expressed genes of DEFA5 and DEFA6, we found that the co-expressed genes shared by DEFA5 and DEFA6: KLK12, PTGDR2, ATOH1, OLFM4, and CLCA1were involved in tumor formation, inflammatory response, transcriptional regulation, inhibition of cell growth, induction of cell differentiation and apoptosis, and promotion of cell adhesion and tumor inhibition.