Compared with that in normal tissues, the fold change of DEFA1 was 1.235 in colon cancer (Zou Colon Dataset) (34), 1.261 in CRC (Skrzypczak Colorectal Dataset) (35), 1.270 in colonic mucinous adenocarcinoma (Kaiser Colo Dataset) (36), 1.171 in colonic adenocarcinoma (Kaiser Colo Dataset) (36), and 1.442 in CRC (TCGA Colorectal Statistics). Here, DEFA1 is linked to malignant colon neoplasm.