The following percutaneous biopsy of the mass demonstrated a proliferation of phenotypically aberrant population of large cells that expressed CD30 and CD45, negative for CD3, CD20, and ALK1, diagnostic for anaplastic large cell lymphoma, ALK-negative (ALK-ALCL) (Figures 2A, B) (8). The gene discussed is TNFRSF8; the disease is anaplastic large cell lymphoma.