The function of MXRA8 in cancer development and progression has not been addressed, but it has been reported to be highly expressed in thyroid cancer (22), kidney cancer (15), esophageal cancer (23), and pancreatic cancer (24), Therefore, this study is the first report on the high expression of MXRA8 in CRC. The gene discussed is MXRA8; the disease is colorectal carcinoma.