GCK and type 2 diabetes mellitus: In addition, GCK regulates glucose-stimulated insulin secretion, giving attention as a candidate gene for T2DM.11Although a variety of candidate genes have been demonstrated to be in association with the development of T2DM in diverse populations, some of the genes such as glucokinase regulatory protein (GCKR), glucose-6-phosphatase 2 (G6PC2), andGCKare not well studied, particularly among Asians.