Based on systems pharmacology studies, Ti et al. (2021) discovered that the anti-influenza activities of Curcumae Rhizoma may be achieved by regulating phosphatidylinositol-3-hydroxykinase (PI3K) protein kinase B (Akt) and tyrosine kinase (Jak)-transcription factor (STAT) signaling pathways. The gene discussed is AKT1; the disease is influenza.