Effectively regulate the expression of TGF-β1, α -smooth muscle actin (α-SMA) and collagen-III; reduces extracellular matrix and collagen fiber deposition, and relieves bleomycin-induced pulmonary fibrosis in mice; promoting the expression of autophagy related proteins LC3B-II and Beclin1 and inhibiting the PI3K/Akt/mTOR signaling pathway may. The gene discussed is TGFB1; the disease is pulmonary fibrosis.