Based on our summary of the anti-microbial mechanisms of Curcumae Rhizoma, the therapeutic mechanisms of Curcumae Rhizoma may be achieved through inhibition of viral NP protein, regulation of the PI3K/Akt/mTOR signaling pathway, direct inactivation of the virus, inhibition of relevant inflammatory factors, and anti-pulmonary fibrosis. The gene discussed is AKT1; the disease is pulmonary fibrosis.