IL6 and immune system disorder: In addition, immunogens and allergens stimulate the body to secrete inflammatory factors such as IL-6 or IL-23, stimulate JAK-STAT pathway, and generate activated p-STAT3 to promote the expression of Th17 transcription factor-RORγT in T-lymphoid subsets, which can promote the expression of inflammatory factors such as IL-17, aggravate the occurrence of immune diseases (Dhanushkodi et al., 2020), inhibit the activation of JAK-STAT3 pathway, and improve the symptoms of AD lesions (Li et al., 2021).