IGHE and Alzheimer disease: In this study, after the intervention treatment with different doses of OMT in mice, it was found that the serum inflammatory factors IgE, TNF-α, IL-4 and IL-7 decreased, the positive expression of CD3 in skin tissue decreased, and the pathological damage such as skin epidermal hyperplasia and inflammatory cell infiltration also eased significantly, indicating that OMT has potential application value in the treatment of AD.