STAT3 and Alzheimer disease: The expression of SOCS1 in the ear skin of mice in the OMT-H, OMT-M and OMT-L groups increased, and the expression of JAK-STAT3 pathway and T lymphoid activation related promoters decreased, suggesting that OMT could improve AD skin inflammation symptoms, which may be related to the up regulation of SOCS1 expression, inhibition of JAK-STAT3 pathway and T lymphoid activation.