HSPA5 and coronary artery disorder: Kaempferol is another subtype of flavonol and natural anti-oxidant that has been proven to have an inhibitory effect on ER stress proteins, such as GRP78, ATF-6alpha, and CHOP and an anti-apoptotic effect by regulating B-cl2 and Bax proteins, which can explain its impressive role in protection against ischemic heart disease.