COL3A1 and triple-A syndrome: In addition, approximately 20%–25% of TAA patients are estimated to have familial TAAs, and considerable proportion (∼25%) of the familial cases exhibit an autosomal dominant pattern of inheritance of the disease within the family, i.e., thoracic aortic disease caused by a mutation in a single gene (Marfan syndrome due to FBN1 mutations, COL3A1 mutations related to vascular Ehlers–Danlos syndrome) (Pinard et al., 2019), whereas AAA does not typically demonstrate such inheritance.