COL3A1 and aneurysm: Accumulative studies have shown that genetic variants in proteins (COL3A1, FIBRILLIN-1, and so on) directly affect the mechanical properties of the aorta, ultimately leading to TAA (Malfait, 2018), reflecting that adventitial fibroblasts, as the main producer of ECM, might be related to the pathogenesis of aneurysm.