DZ leaves are effective against secondary hypertension, such as renal hypertension and salt-sensitive hypertension, as well as hypertension caused by thoracic aortic endothelial dysfunction, high-fat diets, and oxidized low-density lipoprotein by regulating the Ras homolog family member A/Rho-associated protein kinase signaling and NO/soluble guanylate cyclase/cyclic guanosine monophosphate signaling pathways (Li et al., 2022). Here, RHOA is linked to secondary hypertension.