Recent studies have found that lignans, flavonoids, and iridoids from DZ exert hypotensive effects, potentially due to inhibiting oxidative stress, improving endothelial dysfunction, regulating the autonomic nervous system, activating ion channels, and regulating the renin-angiotensin-aldosterone (RAAS) system (Sih et al., 1976; Li et al., 2013; He et al., 2014; Hosoo et al., 2015). This evidence concerns the gene REN and endothelial dysfunction.