Of 33 antibodies to neural and tight junction proteins, actin immunoglobulin G (IgG), occludin/zonulin (OZ) immunoglobulin A (IgA), OZ IgG, myelin oligodendrocyte glycoprotein (MOG) IgG, MOG immunoglobulin M (IgM), myelin basic protein (MBP) IgA, MBP IgG, astrocytic protein (S-100) IgG, S-100 IgM and cerebellar antigen (CEREB) IgG in serum, and MBP antibodies in CSF were higher in children exposed to high levels of PAH compared to controls (58). This evidence concerns the gene CD40LG and pulmonary arterial hypertension.