Age‐related changes in the sAHP have been linked to cognitive impairments in rabbits, rats and mice (for reviews, see (Disterhoft & Oh, 2007; Dunn & Kaczorowski, 2019; Foster, 2019; Moore & Murphy, 2020; Oh et al., 2010)).To determine to what extent the overexpression of CaV1.3 (and the resulting enhanced sAHP) might impact cognitive function, CaV1.3Tg− and CaV1.3Tg+ mice were evaluated in several learning and memory tasks, which are known to be sensitive to aging. Here, CAV1 is linked to Cognitive impairment.