CD4 and Alzheimer disease: For example, Aβ-specific CD4+ T helper 1 (TH1) cells induce a major histocompatibility complex class II (MHC II)+ population of microglia that abrogate AD-like pathology in the 5XFAD mouse model, likely due to interferon gamma (IFN-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\gamma$$\end{document}γ) cytokine signaling [223].