MLKL and breast neoplasm: While the depletion of CD8+ T cells had no effect on lung metastasis of the WT MMTV-PyMT and MVT-1-CRISPR-CT tumors, however, the loss of CD8+ T cells in mice with Mlkl KO MMTV-PyMT and Mlkl KO MVT-1 tumors leads to the restoration of the metastasis of breast tumor cells to the lung almost as efficiently as their WT counterparts (Fig. 3b and Additional file 1: Fig. S3b).