Because the effect of KLRG1 neutralization on T cell activity and lung metastasis is comparable to that as due to MLKL deletion or ADAM inhibition, KLRG1, not the PD-1, pathway likely plays a major role in necroptosis-mediated inhibition of T cell anti-tumor activity and the promoting effect on metastasis. This evidence concerns the gene KLRG1 and neoplasm.