Besides, studies also discovered mutations in ASXL1, DNMT3A, EZH2, RUNX1, TET2 and TP53 genes in the chronic phase of CML, and in CBL, CDKN2A, GATA-2, IDH1, IDH2, IKZF1, KRAS, NPM1, NRAS, RB1, RUNX1, TET2, TP53 and WT1 genes in the advanced phase [13, 14]. This evidence concerns the gene TP53 and chronic myelogenous leukemia, BCR-ABL1 positive.