According to the study results, the highest ASIR of renal cancer among Iranian men is observed in Fars (3.81 per 100,000), and the highest ASIR among Iranian women occurs in Ardabil province (2.9 per 100,000) [7].Over the past decade, medical treatment for renal cell carcinoma (RCC) has altered from a nonspecific immune approach (in the cytokine era) to a more specific therapy against vascular endothelial growth factor (VEGF) and currently to novel immunotherapy agents. This evidence concerns the gene VEGFA and hereditary clear cell renal cell carcinoma.