On the other hand, their effects were significantly negative on proliferation (% Ki67+ cells) [time to last visit or conversion: beta = −1.24, 95% CI: −1.59 to −0.89, t(155) = −7.03, P < 0.001; MCI to Alzheimer’s disease progression: beta = 5.58, 95% CI: 2.53 to 8.63, t(155) = 3.61, P < 0.001]. This evidence concerns the gene MKI67 and early-onset autosomal dominant Alzheimer disease.