Among the differentially expressed proteins, there were proteins involved either in the neurogenic process (e.g. GDF11) or in Alzheimer’s disease (e.g. LRRK2, RCAN1, NTRK2), or in both neurogenesis and Alzheimer’s disease (e.g. CREBBP, SFRP1, IL1RAP). The gene discussed is IL1RAP; the disease is early-onset autosomal dominant Alzheimer disease.