On the other hand, their effects were significantly positive on the number of mature neurons (% MAP2+ cells) [time to last visit or conversion: beta = 0.56, 95% CI: 0.11 to 1.02, t(153) = 2.47, P = 0.015; MCI to Alzheimer’s disease progression: beta = 2.96, 95% CI: 0.62 to 5.31, t(153) = 2.50, P = 0.014]. The gene discussed is MAP2; the disease is early-onset autosomal dominant Alzheimer disease.