Nevertheless, our data showing increased proliferation in MCI converters during the differentiation stage of the assay are in line with a recent rodent study that investigated HN in ‘prodromal’ Alzheimer’s disease, where proliferation of DCX+ neuroblasts in the hippocampus was significantly and specifically ‘elevated’ during the pre-plaque stage in the APP-PS1 mouse model.25 Intriguingly, we observed an increased average cell number and a decreased percentage of proliferating cells with each consecutive visit. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.