RIG-I-like receptors (RLRs), including retinoic acid-inducible gene I (RIG-I), melanoma differentiation-associated protein (MDA)-5, and laboratory of genetics and physiology gene 2 (LGP2), are a series of cytosolic RNA sensor that detect multiple viral RNAs accumulated during viral infection or replication. This evidence concerns the gene RIGI and viral infectious disease.