Liede et al. examined 257 (13.2%) BM patients among 2,097 stage I - III BC patients in their follow-up period (median = 12.5 years) to show that bone as the first metastasis site was associated with ER+ (Hazard Ratio [HR] = 1.85, p =0.008), but not with PR+ (HR = 0.79, p =0.20) through multivariate analysis [10]. The gene discussed is ESR1; the disease is breast cancer.