According to cBioPortal database, APC is the top 1 mutated tumor suppressor gene in colon adenocarcinoma (COAD, 68.6% mutation rate) and CTNNB1 (30.6% mutation rate) is the most frequently mutated proto-oncogene in hepatocellular carcinoma (HCC) [14, 15]. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.