Two of the subclusters described by the authors were significantly overrepresented by these 14 SNPs: 5 (ARAP1, ADCY5, PPARG, TCF7L2, KCNJ11-NCR3LG1) were in the subcluster characterized mainly by higher BMI and lower fasting glucose and risk of T2D (enrichment P = 1.6 × 10−3) and 4 (GRB14, LYPLAL1, ADAMTS9 and VEGFA) in the subcluster that conveyed an apparent protective effect on multiple cardiometabolic traits via peripheral adipose distribution (higher BMI and body fat percentage, and lower WHR; enrichment P = 0.04). This evidence concerns the gene LYPLAL1 and type 2 diabetes mellitus.