CRTC1 and carcinoma: Indeed, mTOROID-like regulation could explain why mTORR2266P and possibly RaptorD635N are associated with carcinoma, based on our finding that substitution of the analogous residue in Tor1W2203R Tor2W2207R generated cells that did not form TOROIDs and appeared to possess hyperactive TORC1 signaling (that is, were resistant to rapamycin).