Interestingly, induction of T cell recruiting chemokines, such as CXCL9/10/11 and certain ISGs, has also been observed in preclinical CRC mouse models following KRASG12C inhibition30, suggesting that this tumor cell-intrinsic transcriptional response may be a key mechanism more broadly linked to inhibition of the RAS–MAPK pathway. Here, CXCL9 is linked to neoplasm.