TP53 and medulloblastoma: However, not all TP53 germline mutated tumors in this cohort showed SBS2 or SBS13 activity, including the TP53-defined subtype of SHH-medulloblastoma (see Supplementary Table 8 for an overview of tumors with TP53 mutations), suggesting tissue-specific association of TP53 mutations and APOBEC signature activities.