Elevated plasma levels of Tumor Necrosis Factor alpha (TNF-α), Interleukin (IL)-2, IL-6, IL-10, granulocyte colony stimulating factor (G-CSF), galectins and C-reactive protein (CRP), procalcitonin (PCT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), D dimer, urea, creatinine, Ferritin and lymphopenia in early stage are associated with disease progression to critical illness3,6. The gene discussed is TNF; the disease is lymphopenia.