The univariate logistic regression analysis showed that age (> 65 years), dyspnea, chest pain, attenuated breathing sound, audible cracks diffusely, platelet count, lymphocyte, albumin, urea, creatinin, d-dimer, CRP, PCT, IL-1β (> 120 pg/mL), IL-10 (> 300 pg/mL), TNF-α (> 65 pg/mL) and Gal-3 (> 5000 pg/mL) were associated with critical stage of COVID-19 (Table 5). This evidence concerns the gene IL1B and COVID-19.