Multivariate logistic regression analysis identify that Gal-3 (OR 2.97, 95% CI 1.006–8.764; p = 0.049), IL-10 (OR 3.117, 95% CI 1.119–8.105; p = 0.020), creatinine (> 100 umol/L) (OR 4.035, 95% CI 1.549–10.506; p = 0.004), platelet count (< 100 × 109/L) (OR 9.608, 95% CI 1.255–73.535; p = 0.029), chest pain (OR 4.964, 95% CI 1.158–21.278; p = 0.031), attenuated breathing sound (OR 4.703, 95% CI 1.601–13.812; p = 0.005) and audible cracks diffusely (OR 2.467, 95% CI 1.006–6.048; p = 0.048) were independently significant factors for critical stage of COVID-19. The gene discussed is IL10; the disease is COVID-19.