There is also evidence in rodents directly relating chemokines and their receptors to these behaviors, with prenatal administration of Cxcl12 into the third ventricle shown to induce novelty-induced locomotor activity and anxiety-like behaviors49, deletion of the chemokine receptor Ccr2 reducing preference for ethanol28, and antagonism of the Cxcr4 receptor blocking cocaine-induced locomotor activity and conditioned place preference50. Here, CXCL12 is linked to Anxiety.