Lastly, differential expression between clinical groups within the GZMB + CD8+ effector T-cells subset showed significant enrichment of multiple genes related to cytotoxicity and T-cell activation in NP samples (GZMB, GNLY, TNF), potentially indicating a better effector function and T-cell activation in NPs (Supplementary Fig. 20, Supplementary Table 2). Here, GZMB is linked to nail-patella syndrome.