The “cold” immune milieu is featured with abundant immunosuppressive cells and factors, including tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), interleukin-10 (IL-10), and transforming growth factor-β (TGF-β) et al., which are unfavorable for the recruitment and infiltration of effector T cells6,7,10,12. This evidence concerns the gene IL10 and neoplasm.