CD8A and neoplasm: The involvement of specific type of T cells for the Nano-reshaper mediated tumor control was further confirmed through the depletion study, in which anti-CD8 antibody (αCD8) significantly compromised the therapeutic efficacy of Nano-reshaper compared to the IgG control, but little effect was observed on anti-CD4 antibody (αCD4) (Fig. 7f–i).