Although there was no significant improvement in inflammatory markers and oxidative stress in cardiac tissue (Table 3), except for the reduction of IL-6 in MetS+O (Table 3), it is important to highlight that for the first time IL-10 was evaluated in cardiac tissue from Zucker rats, and was observed an increase in concentration in all groups composed of fa/fa animals. In addition to IL-10 attenuating the induced oxide synthesis and apoptosis in cardiac tissue, studies have shown that IL-10 concentration in human serum is diminished in individuals with cardiac comorbidities67,68. The gene discussed is IL10; the disease is metabolic syndrome.