Recently, using an autophagy loss switchable GEMMs for KrasG12D/+;p53-/- (KP) NSCLC, we demonstrated that transient systemic autophagy ablation is selectively and irreversibly deleterious to lung cancer by impairing lung tumor cell metabolism and promoting T-cell mediated tumor killing [37]. Here, TP53 is linked to non-small cell lung carcinoma.