PNMT and neoplasm: As seen in Figure 4B, the oncogene ERBB2 showed several strong RNAPII-mediated interactions with nearby genes, such as PGAP3, STARD3, and PNMT. Compared with neighboring or distant genes not in the interaction domain, genes with ERBB2 interactions demonstrated obvious coexpression patterns in the LUAD tumor samples (Figure 4C), whereas similar coexpression patterns were not observed in normal samples (Figure S4A).