Moreover, studies have shown that the Ki67 index of non-GCB DLBCL tumor cells is significantly higher than that of GCB, indicating that the prognosis of non-GCB DLBCL is worse than that of GCB DLBCL.[15] MUM-1 is a transcription factor in the interferon regulatory factor family, which is usually expressed in plasma cells and plays an important role in gene regulation. This evidence concerns the gene IRF4 and diffuse large B-cell lymphoma.