Moreover, studies have shown that the Ki67 index of non-GCB DLBCL tumor cells is significantly higher than that of GCB, indicating that the prognosis of non-GCB DLBCL is worse than that of GCB DLBCL.[15] MUM-1 is a transcription factor in the interferon regulatory factor family, which is usually expressed in plasma cells and plays an important role in gene regulation. The gene discussed is IRF4; the disease is neoplasm.