Exercise is well-known to be one of the most effective nonmedical means of vascular protection and has a strong impact on vascular function.[17,18] Indeed, exercise has a positive direct effect on blood flow (BF), vascular reactivity, vascular endothelial growth factor (VEGF) and angiogenesis, upregulating NO bioavailability and growth factor expression.[19,20] There is growing interest in the beneficial effects of exercise on vascular and cognitive function in patients with AD. This evidence concerns the gene VEGFA and Alzheimer disease.