EGFR and non-small cell lung carcinoma: Relevant reports indicated that NSCLC patients with EGFR gene amplification have a higher probability of EGFR gene mutation, and EGFR gene mutation can cause an increase in the copy number of part of the gene.[17,18] Cappuzzo and Eberhard also found that patients with EGFR gene amplification and higher copy number of non-small cell lung cancer have a better curative effect on EGFR-TKI, but they did not investigate the relationship between the EGFR gene amplification and targeted therapy in detail.[19,20]