Abedi-Ardekani et al examined tumor tissue specimens from 152 patients with esophageal squamous carcinoma by direct sequencing which detected 1 case of EGFR19 exon E746 to A750 deletion with a mutation rate of 0.7%.[11] Liu et al used the ARMS method to detect EGFR mutations in the specimens of 50 patients with esophageal squamous cell carcinoma.[12] The results showed that there were 7 cases (14%) of EGFR mutation patients, of which 2 cases had exon 19 E746 to A750 deletion, and 5 cases were extra 21 Exon L858R point mutation. The gene discussed is EGFR; the disease is esophageal squamous cell carcinoma.