The anti-emetic effects of acupuncture apparently stem from the resultant increase in hypophysial secretion of beta-endorphins and ACTH, with subsequent inhibition of the chemoreceptor trigger zone and vomiting center.[6] Considering the autonomic nervous system is involved in the peripheral mechanism of nausea and vomiting, vagal modulation through Neiguan (PC6) has been proved effective.[7] Furthermore, acupuncture has fewer side effects than antiemetics, which may be the most advantageous factor compared with medication for cancer patients.[8]. This evidence concerns the gene POMC and cancer.