Metallothionein is involved in zinc homeostasis in vivo,[20] but metallothionein has been shown to be 25% to 30% lower in liver with cirrhosis than in normal liver tissue.[21] Zrt- and Irt-like protein-4 is involved in zinc homeostasis.[22] The present analysis revealed a weak inverse correlation between serum zinc levels before and per-dose increase after zinc administration in patients with cirrhosis, indicating that this maintenance mechanism is preserved even in the presence of cirrhosis. Here, SLC39A4 is linked to Cirrhosis.