TNF and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Neuroinflammation has not been specifically examined in the Scn1a+/- mice studied here, but recent research suggests that neuroinflammation occurs in the Syn-Cre/Scn1aWT/A1783V mouse model of Dravet syndrome, as evidenced by increased microgliosis, astrogliosis and expression of the proinflammatory cytokine, TNFα [33].