Indeed, the Rho-type GTPase Activating Protein 1, ARHGAP1, which was not found to be regulated by miR-130b in LMS cells (Fig 3B), has been identified as a direct target of miR-130b in Ewing Sarcoma, where upregulation of this miRNA leads to enhanced invasion and metastasis via stimulation of the CDC42/PAK1/AP-1 axis [58]. This evidence concerns the gene PAK1 and Ewing sarcoma.