Interestingly, Jeon et al. reported that the LCN2 receptor 24p3R is expressed by neurons in the spinal cord (31), suggesting that microglia-derived LCN2 likely activates the 24p3R in the spinal neurons and promotes synaptic plasticity through microglia-neuronal crosstalk in the setting of peripheral nerve injury-induced neuropathic pain. The gene discussed is LCN2; the disease is Pain.