CYP1A2 and hypertensive disorder: More than 95% of caffeine is metabolized by cytochrome P450 1A2 (CYP1A2) and a common polymorphism in the CYP1A2 gene has been reported to be significantly associated with caffeine metabolism.24 The rs762551 variant decreases enzyme activity and inducibility.24,25 Individuals with AC and CC genotypes are considered slow metabolizers, and those with the AA genotype are considered fast metabolizers.26 This polymorphism has been found to modify the association between coffee intake and the risk of myocardial infarction,27 hypertension,28 and impaired fasting glucose29 in a dose-dependent manner.