Those findings might explain some of the inconsistencies observed in reports of coffee intake and kidney disease; however, previous studies examining the association between coffee and the risk of kidney disease have not examined the role of CYP1A2. The objective of the present study was to assess whether CYP1A2 genotype rs762551 modified the association between intake of caffeinated coffee and markers of kidney dysfunction. This evidence concerns the gene CYP1A2 and kidney disorder.