CYP1A2 and hypertensive disorder: In a large cohort of South Korean participants, coffee consumption was only protective against kidney disease in older diabetic women, and no association was found between coffee intake and kidney disease in other groups.51 In the present study of young adults with prehypertension to moderate hypertension who only received lifestyle intervention to manage hypertension, we observed an association between heavy coffee consumption and hyperfiltration that was modified by CYP1A2 genotype.