However, when stratified by genotype, the risk of developing hypertension in slow metabolizers increased significantly with heavy coffee drinking (Cox regression model: unadjusted HR, 2.39 [95% CI, 1.34-4.29; P = .003]; model adjusted for age, sex, baseline BMI, baseline eGFR, and urinary albumin: HR, 2.81 [95% CI, 1.51-5.23; P = .001]) (Figure 3B), while no effect of coffee intake on hypertension was observed in fast metabolizers (Figure 3C). The gene discussed is ALB; the disease is Hypertension.