In this cohort study involving a 7.5-year follow-up of 1180 untreated participants with stage 1 hypertension from the Hypertension and Ambulatory Recording Venetia Study, those with a genetic variant in CYP1A2 who were slow metabolizers of caffeine were 2.7 times more likely to develop albuminuria, 2.5 times more likely to develop hyperfiltration, and 2.8 times more likely to develop hypertension with heavy coffee intake compared with low coffee intake. Here, CYP1A2 is linked to Hypertension.