Interestingly, the activation of the F-actin/DRP1/Nrf-2 axis was shown to be upregulated in breast tumour dormancy models where inhibition of DRP1 and Nrf-2 prevented the dormant-to-proliferative switch, showing the deep impact of mitochondrial dynamics and redox signalling in DTC fate and metastasis. This evidence concerns the gene DNM1L and breast neoplasm.