PPARGC1A and breast cancer: In particular, PGC-1-α can act as partner of p53 influencing the impact of the mutant p53 R72 variant that is associated with poor prognosis on metabolism and metastasis in breast cancer cells, where the mutant p53 enhances migration and metastasis through the ability to bind and regulate PGC-1-α, increasing mitochondrial function [263].