Protein Wnt-5a (Wnt5a) expression in the osteoblastic niche has been found to promote dormancy in a model of prostate cancer via the activation of the Wnt5a/tyrosine-protein kinase transmembrane receptor ROR2 (ROR2)/E3 ubiquitin-protein ligase SIAH2 (SIAH2) signalling axis [163]. This evidence concerns the gene SIAH2 and Familial prostate cancer.