Early abrogation of the SHH pathway using an anti-SHH/Indian hedgehog protein (IHH) antibody 5E1 against Shh, the primary Hh ligand expressed in the lung of KrasG12D/+;Trp53fl/fl autochthonous murine lung adenocarcinoma, led to significantly worse survival with increased tumour and metastatic burden, while genetic deletion of Shh has no effect on survival [357]. This evidence concerns the gene IHH and neoplasm.