Interestingly, Carracedo et al. [182] unveiled the role of promyelocytic leukemia (PML) gene as an inhibitor of peroxisome peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-α) acetylation and as a potent activator of peroxisome proliferator-activated receptors (PPAR) signalling and fatty acid oxidation in breast cancer. Here, PPARGC1A is linked to breast carcinoma.