Mechanistically, hypoxia upregulated the expression of mitogen-inducible gene 6 protein (MIG-6) a negative regulator of ERBB signalling, which prevented heterodimer formation of ERBB family receptor tyrosine kinases (RTKs) and downstream signalling inducing tumour cell quiescence and resistance to EGFR tyrosine kinase inhibitor (TKI) treatment. Here, ERRFI1 is linked to neoplasm.