In most patients with LDL-hypercholesterolemia, with the exception of some patients with severe heterozygous familial hypercholesterolemia or homozygous familial Hypercholesterolemia and some patients with statin intolerance, LDL-cholesterol goals can be achieved if a combination of lifestyle modification, statins, ezetimibe, bempedoic acid, and PCSK9 inhibitors is used [3]. This evidence concerns the gene PCSK9 and familial hypercholesterolemia.