So far, IL-2, IL-7 [127], IL-9 [128], IL-12 [129], IL-13 [130], IL-15 [131], IL-18 [132], IL-21 [133], IL-23 [134], IL-33 [135], and other cytokines have been used in pre-clinical studies in conjugations with CAR-T cells, while some cytokines, such as IL-1 [136, 137], IL-6 [138, 139], IL-10 [140], TNF-α [136, 141], IFN-γ [138], and GM-CSF [142], have some negative effects on CAR-T cell therapy participating in the development of CRS during CAR-T cell therapy. Here, IFNG is linked to congenital rubella syndrome.