After treating hepatic stellate cells and vascular endothelial cells with BMP9, the levels of inflammatory factors (IL-6, IL-8, and TNF-α), chemokines, and inflammatory signaling pathways significantly changed.14 BMP9 also reduced cancer metastasis by inhibiting the inflammatory microenvironment.15,16 Currently, there are few studies on BMP9 and dental inflammatory diseases. The gene discussed is GDF2; the disease is cancer.