,47 In contrast, Roborovski hamsters (Phodopus roborovskii), similar to transgenic human ACE2 hamsters, develop severe respiratory and systemic disease and death, presenting clinical respiratory signals like the severe human COVID-19: snuffling, laboured breathing, anosmia, dyspnoea, cough, hunched posture, progressive weight loss, ruffled fur, fever, and shaking chills, with right-predominated interstitial pneumonia and slight damage to the brain and liver.48 This evidence concerns the gene ACE2 and COVID-19.