Subsequent findings revealed that the aforementioned rats presented with increased LVEF% and LVFS%, normal myocardial fiber arrangement, alleviated cardiomyocyte interstitial edema, and quenched inflammatory cell infiltration, in addition to diminished myocardial infarction area and decreased levels of CK-MB, cTnI, and LDH levels; meanwhile, the H9c2 cell model exhibited augmented cell viability, quenched apoptosis rate, restricted CK-MB and cTnI levels and eliminated LDH release. Here, TNNI3 is linked to myocardial infarction.